theta2

THeTA2 (Tumor Heterogeneity Analysis) is an algorithm that estimates the tumour purity and clonal / subclonal copy number aberrations directly from high-throughput DNA sequencing data.

The THeTA2 MultiQC module plots the % germline and % tumour subclone for each sample. Note that each sample can have multiple maximum likelihood solutions - the MultiQC module plots proportions for the first one in the results file (*.BEST.results). Also note that if there are more than 5 tumour subclones, their percentages are summed.